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The before and after results were impressive, and together with another steroid Anadrol, it became the treatment of choicefor a number of patients with Crohn's disease. However, it proved tough to use. Not only was the product's potency, particularly to the gut, low, but it was found to have an unfair side-effect, too: it caused severe stomach upset. In addition, the patient became dehydrated, and required a larger dose over the course of the day. To make matters worse, the high doses did not last long on the stomach-dilating effects, with patients having to be dosed up several times more over the course of a day. Although many patients took it, it did not seem to work for them. The treatment worked well for a while, but the side-effects were not conducive to a success-rate, and the product was dropped. Fast forward to 2010, when two Danish researchers decided to try a new treatment for the condition: a drug that has the greatest combination of effects: 'Tissue-destroying' steroids To get an idea of what they are, first you have to understand the basics of the disease. A group of intestinal cells called villi are surrounded by a thin tissue called villomere. Once they become damaged, they can no longer maintain homeostatic balance. This causes the cells inside the intestine to malfunction and eventually burst, giving way to blockages, and the damage continues until the villosomere's own cell death occurs, causing leakages and an uncontrolled release of the inflammatory cytokine, TNF. Most of the diseases we have considered 'intestinal' are indeed caused by an intestinal disorder, but not all. The inflammatory process that begins in the intestine ends up extending through the entire body and is sometimes called colonic inflammation. However, in Crohn's disease, the inflammation doesn't start in the intestines but rather in the lymph nodes and the blood stream. By combining a number of drugs, the researchers set out to create a treatment that would be more effective than any available alone. They first had to establish a protocol suitable for a single clinical trial. This involved making several injections of a single drug, a process involving the use of a mouse model, and then making three intravenous infusions, one injection each day for three days. This allowed researchers to check if the medication's mechanism of action, as observed in mice, would be replicated on a human being. The treatment in their experiment was then tested at six sites in the United Similar articles:

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